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the most significant structural differences were observed in the extracellular regions (Fig

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Despite their potential benefits, the risk of psychiatric adverse effects requires cautious administration

This expanded approval is based on results from the pivotal FLOW phase 3b clinical trial, which demonstrated that once-weekly semaglutide led to a statistically significant 24% reduction in the risk of kidney disease progression, kidney failure, and cardiovascular death compared to placebo, when added to standard care