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Some data also suggests that, if started early in the course of ALS, an ultra-high-dose of methylcobalamin may prolong ventilation-free survival

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Excluded were those mothers who anticipated moving out of the area before study completion, who had twin or multiple pregnancies, who were treated for infertility, who tested positive for hepatitis B (hepatitis B surface antigen), HIV, or syphilis (Venereal Disease Research Laboratory test) infections, or who were taking daily vitamin supplements in addition to folic acid and iron

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