All consultations and prescriptions are carried out by GMC registered medical practitioners
The position this article takes, given those three valid critiques, is that the mechanism evidence is strong enough, the delivery evidence is biologically plausible enough, and the safety window is wide enough that the recommendation is defensible
Neuroimaging should be further incorporated into antidepressant clinical trials to determine whether clinical outcomes in LLD or in depression associated with neurodegenerative diseases are mediated by changes in synaptic density, network connectivity, inflammation and other mechanisms and to map these mechanistic changes onto clinical outcomes to guide early, targeted intervention
Typical dosing: Weekly, gradually titrated Common side effects: Nausea, reflux, constipation, diarrhea, reduced appetite Important note: Coverage and cost vary
doi: 10.1016/j.jbc.2022.102838