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Acknowledgements This work is supported by DST/SERB-SRG file no

Many studies have found that plant allelochemicals are inducers of phase II detoxification enzymes in herbivorous arthropods [5-7]

Activates AMPK (The Metabolic Master Switch) MOTS-C activates AMP-activated protein kinase (AMPK) often called the metabolic master switch. AMPK activation: Increases glucose uptake into cells (improving insulin sensitivity) Enhances fat oxidation (fat burning) Increases mitochondrial biogenesis (creating new, healthy mitochondria) Reduces inflammation Promotes autophagy (cellular cleanup and renewal) This is the same pathway activated by exercise and calorie restriction two of the most powerful interventions for metabolic health and longevity

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Furukawa et al., 2006