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To boost glutathione levels, people may consider consuming foods rich in the amino acids required for its synthesis, such as cysteine-containing foods (e.g., garlic, onions, cruciferous vegetables) or take glutathione supplements (though the effectiveness of oral supplementation is debated)

CagriSema, under investigation for people with obesity as well as type 2 diabetes, has also shown weight loss (up to 15.6% reduction) as well as improved A1C (up to 2.18% reduction) in its phase 2 clinical trial

If you are deficient in any of these nutrients, direct glutathione supplementation may not be broken down or recycled efficiently

It is also used in glutamate-cysteine ligase regulation and Nrf2/ARE pathway work, where glutathione acts as the feedback inhibitor of its own synthesis (Lu, Biochimica et Biophysica Acta, 2013)

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