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The following table summarizes common claims and their evidence basis: The key pattern: most benefits are real only for individuals who are actually deficient in B12

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The reasons: Receptor sensitivity: While GHK-Cu doesn't appear to cause receptor downregulation the way some peptides do, cycling is a general precaution to maintain responsiveness and avoid adaptations that might blunt benefits

The rich network of blood vessels in this region carries the peptide directly into systemic circulation