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In people with major depressive disorder and a chronic physical condition, mitochondrial ATP production decreases in muscle cells.[ref] Another post-mortem study on the brains of patients with depression, bipolar, or schizophrenia showed a specific mitochondrial protein (NDUFS7) involved in ATP production decreased significantly in patients with bipolar disorder.[ref] Ketogenic diet: A ketogenic diet is very low in carbohydrates, which causes a shift in the way that mitochondria produce energy

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Experiments showed that knocking down FTO in adult hippocampal neurons induced depression-like behavior, while overexpressing FTO reversed such behavior in response to unpredictable chronic mild stress

J Nucl Med 49:19992005

It creates pain, numbness, weakness, and tingling as it passes through the carpal tunnel and can have a significant impact on a persons daily life