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Furthermore, open-label trials utilizing high-dose hydroxycobalamin have shown marked clinical improvements in ME/CFS patients, specifically correlating with the vitamin's ability to act as a nitric oxide scavenger

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En cuanto a su farmacologa experimental, la inhibicin de NNMT y la consiguiente alteracin del eje NAD+/SAM son efectos que se estudian de forma controlada en modelos, sin que ello implique inferencias sobre efectos en organismos humanos