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Leptin, which is produced by fat cells and helps regulate sleep architecture, drops as fat mass decreases

Safety and pharmacokinetics of single and multiple ascending doses of the novel oral human GLP-1 analogue, oral semaglutide, in healthy subjects and subjects with type 2 diabetes

Arthritis Rheum (2008) 58(7):203040

Interestingly, a comparison of acute metabolic responses with the chronic profiles at the end of the treatment period strongly suggests that while the different GLP1-based agonists may share primary mechanisms of action, the durability and efficiency of their long-term metabolic responses differ, with clear superiority for the GLP1/E compound