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BMJ 2009

Peptides are prone to proteolytic degradation

Some experienced users reduce dose or frequency once they reach a desired pigmentation level, essentially shifting from PKdriven (pharmacokinetic) thinkinghow long is it in my blood?to PDdriven (pharmacodynamic) thinkinghow stable is my tan and how little do I need to maintain it? No matter the schedule, from a safety perspective, slow titration, long gaps between dose changes, and strict vigilance over mole changes or systemic side effects are minimum safeguards

While this may seem like bad news, this does not mean a blanket no for weight loss drugs