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[18] [19] As you lose substantial amounts of fat, particularly subcutaneous fat beneath the skin, your body's natural insulation decreases, making you more susceptible to feeling cold in environments that previously felt comfortable

Key Takeaways Semaglutide can make you tired and cause fatigue, especially when your body is first adjusting to this class of weight loss medications

[1] [2] As patients lose weightparticularly adipose tissuethe body's natural insulation decreases, and basal metabolic rate may decline

Well also check in with you regularly to monitor progress and ensure everything is working as it should

This is where Zofran might help