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These include improvements in blood glucose control, reductions in blood pressure, and better overall metabolic function

[8] Hydration status: Gastrointestinal side effects such as vomiting and diarrhoea increase the risk of dehydration, which is a well-recognised contributor to fatigue

Androgen/AR complex binding to antioxidative response elements (AREs) containing promoters of target genes disrupts Wnt agonist/antagonist balance involved in DPC-inductive ability, such as dickkopf-1 (DKK1), which is a specific inhibitor of Wnt coreceptors of the LRP family 29

PLoS ONE 8(7):e68271 Hynes M, Porter JA, Chiang C, Chang D, Tessier-Lavigne M, Beachy PA, Rosenthal A (1995) Induction of midbrain dopaminergic neurons by Sonic hedgehog

Published clinical data supports accelerated initial response with the combination approach