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This supports the hypothesis that ciliopathies, such as BBS, involve intrinsic defects in leptin and insulin pathways that are exacerbated, rather than solely caused, by obesity

The aberrant expression of circScd1 affects hepatocellular lipidosis and promotes fatty liver through the JAK2/STAT5 pathway [59]

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New fat-burning diabetes pill protects muscle and appetite Date: December 7, 2025 Source: Karolinska Institutet Summary: Researchers have developed a new oral drug that boosts metabolic activity in muscle rather than altering appetite like GLP-1 drugs