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Of note, levels of soluble DPP4 are increased by DPP4is in mice 72

Rapid weight loss, which can occur with GLP-1 medications, can also sometimes lead to a loss of lean muscle mass and bone density if not managed correctly

These effects were associated with increased F-actin formation and activation of focal adhesion kinase (FAK) and paxillin phosphorylation, signaling events central to cell attachment and cytoskeletal remodeling during tissue repair processes [4]

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Savage et al., 1998), even as newer drugs with fewer, if any, metabolic issues (e.g., ACE inhibitors, calcium channel blockers and -blockers) began to replace it (Officers et al., 2002