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From a pharmacological standpoint, several considerations are relevant: Gastrointestinal effects : Retatrutide, like other GLP-1-based therapies, commonly causes nausea, vomiting, diarrhoea, and reduced appetite

Timeline expectations: 48-72 hours (increased energy and reduced appetite), 1-2 weeks (initial weight loss 2-4 pounds), 4 weeks (noticeable body composition improvements), and 6 weeks (sustained metabolic enhancement and continued fat loss)

Flushing: Temporary redness or warmth in the face or chest

The most commonly reported effects are mild injection site reactions (redness, minor swelling), occasional headaches during the first few days, and rare instances of mild fatigue

It should be given in a clean, clinical setting to reduce the small risk of infection or irritation at the injection site