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However, in women it occurs more commonly on the extremities, and in men it occurs most commonly on the trunk or head and neck.[4] Early signs in a nevus that would suggest a malignant change include: Darker or variable discoloration

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Antimicrobial peptides are synthesized constitutively or after stimulation by proinflammatory or pathogen associated molecules in circulating phagocytic cells, granulocytes, epithelial cells of mucosal tissues, and glandular cells [8, 18]

doi: 10.1200/JCO.18.02306 25 StadlerRLeiterUGarbeC