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Additionally, in an in vitro allergic rhinitis airway epithelial model system of human nasal epithelial cells, IL-13 stimulation in the presence of formononetin treatment (10 M) suppressed upregulated proinflammatory cytokines and mucus formation, potentially though the sirtuin (SIRT1)/Nuclear factor erythroid 2- related factor 2 (NRF2) signaling pathway [119]

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Studies also evaluated the synergistic effect of PERK inhibitors with anti-PD-L1 in the B16F10 tumor model, showing promising outcomes

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