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The side effects were most commonly gastrointestinal disturbances such as nausea and vomiting and occurred in a similar frequency to those reported with dual receptor co-agonists [61]

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"We hope these findings will inspire future efforts to pursue the development of JAK inhibitors for this disease and represent a first rationally-selected treatment based on some exciting new scientific findings." The researchers have not so far observed any adverse effects of ruxolitinib in their small trial, Christiano said

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Nevertheless, its crucial to understand tirzepatide side effects as part of a holistic safety evaluation