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(Article in Japanese) Nardelli S, Riggio O, Gioia S, et al
One promising approach involves targeting lipid metabolic enzymes such as ACSL and utilizing ferroptosis inducers like RSL3
Therefore, effective screening is important for early detection of retinal toxicity
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Since AAVs have been found to integrate within DSBs with high frequency [152], the coupling of CRISPR-Cas9 with AAVs as the delivery vector must be carefully evaluated before clinical translation [58, 153]
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