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If patients treated with EGRIFTA WR develop glucose intolerance or diabetes, consider discontinuing EGRIFTA WR in patients who do not show a clear efficacy response

Dual Incretin Signaling# GLP-1R activation : Enhances glucose-dependent insulin secretion, suppresses glucagon, slows gastric emptying, reduces appetite via hypothalamic signaling GIPR activation : Potentiates insulin secretion, may improve lipid metabolism and fat distribution, enhances central appetite regulation Synergistic effects : The combination produces greater glycemic and weight effects than either pathway alone Pharmacokinetics# The C20 fatty diacid modification enables albumin binding, yielding a half-life of approximately 5 days and supporting once-weekly administration

10.1001/jamainternmed.2019.6969 JAMA Intern Med

This comprehensive review examines 6 research-backed benefits of 5-amino-1MQ, ranked by evidence strength