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The decreased serum level of BDNF after treatment with duloxetine in FM patients supports the overall role of BDNF in pain modulation, probably through complex pain pathways

Tea Catechins improve cognitive abilities, prevent A plaque formation, and offer antioxidant benefits, potentially aiding dementia and AD treatment [18]

Clinical assessments were conducted every 3 months to evaluate efficacy, measured as percentage of total weight loss (%TWL), excess weight loss (%EWL), changes in BMI, and improvement in comorbidities, as well as tolerance, monitored for adverse effects including gastrointestinal symptoms (e.g., nausea, vomiting, diarrhea) and discontinuation rates

RNA sequencing analysis demonstrated extensive transcriptional reprogramming in cold-acclimated T cells, characterized by the upregulation of pathways related to ribosome biogenesis, RNA processing, transcriptional regulation, and protein quality control, accompanied by the downregulation of gene sets involved in DNA replication, DNA repair, and cell cycle progression