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The p300 acetylase is critical for ligand-activated farnesoid X receptor (FXR) induction of SHP

She later tried different things, like cortisone injections

doi: 10.1182/blood-2006-10-055327 146 von VietinghoffSEulenbergCWellnerMLuftFCKettritzR

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In lupus, this autophagy pathway becomes hyperactivated, leading to excessive processing and presentation of self-antigens that fuel the autoimmune response