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Other reasons to contact your provider include: Weight loss that significantly exceeds your prescribed treatment plan Cold sensations accompanied by sweating, tremor, or confusion (possible hypoglycemia, especially if taking insulin or sulfonylureas) Persistent fatigue with pallor or weakness (possible anemia) Severe or persistent symptoms that significantly impact quality of life or do not improve with conservative measures Your healthcare provider can assess whether symptoms represent expected physiological adaptation, require investigation for alternative causes (including blood tests for thyroid function, complete blood count, iron studies, or vitamin B12 levels), or indicate a need for medication adjustment

If the gallbladder was removed due to acute cholecystitis, gallstone pancreatitis, or biliary complications, it is prudent to ensure complete recovery and resolution of any inflammatory processes before initiating weight loss therapy

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Rats genetically prone to obesity, and pigs were treated to induce high blood pressure and fed a salty, fatty diet

Constipation was the most persistent symptom, with some participants reporting ongoing issues throughout the 68-week trial period