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The medication requires strict adherence to prescribed dosing schedules, starting at 2.5mg weekly with careful titration

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The medication significantly slows gastric emptying, which is central to its therapeutic mechanism but may potentially alter the normal digestive processes required for B12 liberation from food proteins and subsequent binding to intrinsic factor

In the large TriNetX cohort study (Vidal/Akiska et al., JAAD International 2026) of 547,993 matched adults, androgenetic alopecia on GLP-1 drugs was raised by a factor of 1.64 after 12 months

It has the dual role of elevating the level of insulin and declining glucagon for the management of glycemic control