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Give tirzepatide a minimum of 16 weeks at a therapeutic dose (10mg or higher) before evaluating efficacy

(1989): Cocaine: an in vivo microdialysis evaluation of its acute action on dopamine transmission in rat striatum

Demonstrated positive response defined as 5% reduction from baseline body weight (adults) or baseline BMI (pediatrics), or maintenance of weight loss with continued participation in a weight management program that includes lifestyle modification, exercise, and reduced calorie diet

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Mechanisms of action and therapeutic applications of GLP-1 and dual GIP/GLP-1 receptor agonists