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A large prospective cohort study that tracked over 1,700 patients demonstrated that patients who underwent a Roux-en-Y gastric bypass lost an excess 21% of their body mass normalized to their non-surgical matched controls at the 10 year point (corresponding to 35 kg (~77 lbs) greater weight loss)

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214,215 While genetic deletion of CPT1a in T cells does not impair memory CD8 + T cell formation, treatment with etomoxir, a CPT1a inhibitor, significantly reduces mitochondrial oxidative function