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GLP-1s for weight management are now accounting for an average of 10.5% of total annual claims for employers in 2025, up from 8.9% in 2024 and 6.9% in 2023

In general, it's safest to avoid taking NSAIDs if you have: Stomach ulcers or bleeding in your digestive system Kidney or liver disease Gastroesophageal reflux disease (GERD or chronic acid reflux) Crohn's disease or ulcerative colitis Diabetes that isn't yet under control High blood pressure that's hard to manage Bleeding disorders Heart failure A history of heart attack or stroke Pregnancy (or if you plan to get pregnant soon) You drink alcohol every day You have asthma that gets worse when you take aspirin You're 65 or older DMARDs for Psoriatic Arthritis Treatment If your psoriatic arthritis symptoms are mild to moderate or don't respond well to NSAIDs, your doctor may prescribe you a disease-modifying antirheumatic drug (DMARD)

Therefore, aggressive diuretic use and massive fluid restriction may be effective at reducing body weight for a short time, despite concerns of electrolyte imbalance and blood pressure drops during treatment

20 DoveA.ShangY.XuW.GrandeG.LaukkaE.FratiglioniL.et al (2021)

A 29-year-old founder in the same piece switched herself from prescription Zepbound to grey-market retatrutide after a conference session suggested it, citing the pressure of looking good in launch videos