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A study in fat cell metabolism revealed that AMPK activation in the hypothalamus, responsible for appetite regulation, led to reduced food intake in obesity and diabetes while improving fat cell metabolism in diet-induced obese mice

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A 2024 study published in JAMA Ophthalmology reported that patients with Type 2 diabetes who took semaglutide-containing medications had more than a fourfold higher risk for developing non-arteritic anterior ischemic optic neuropathy (NAION) compared with patients not on a GLP-1 agonist