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The formation of osteoclasts is regulated by M-CSF and receptor activator of nuclear factor kappa- ligand (RANKL)

145 Therefore, maintaining gut microbial homeostasis and enhancing both anti-inflammatory and antioxidant capacity may represent promising strategies for delaying immune aging and promoting healthy longevity

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Such knowledge is fundamental for guiding innovative genetic and biotechnological breeding strategies aimed at developing more efficient and resilient cultivars under abiotic stress