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100300 mcg once daily, titrated upward gradually across an 812 week course (often dosed before bed, fasted)

For dosing protocols, see our complete 5-amino-1MQ dosing guide

It introduces more variables and requires a much deeper understanding of the endocrine system

Vitamin B12 deficiency can also be a side effect of metformin, a diabetes medicine, particularly if you take a high dose of metformin or if you take it for a long time

Tried and tested: The Best Vitamin B12 Supplements, According to Dietitians Since B vitamins are found in many foods, you are most likely not at risk of developing a deficiency as long as you follow a well-rounded diet