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Certain GLP-1 formulations have demonstrated cardiovascular benefits in clinical trials, leading to specific FDA approvals: Victoza, Ozempic, and Trulicity are approved for reducing major adverse cardiovascular events in patients with type 2 diabetes and established cardiovascular disease, while Wegovy is approved for cardiovascular risk reduction in adults with established cardiovascular disease and either obesity or overweight

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This prevents the stomach from becoming over-full, which is a primary trigger for acid reflux when gastric emptying is delayed

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