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When infused at a rate to mimic conditions after a meal, the hormone prodded the pancreas to crank out more insulin

Piel S, Chamkha I, Dehlin AK, Ehinger JK, Sjvall F, Elmr E, Hansson MJ (2020) Cell-permeable succinate prodrugs rescue mitochondrial respiration in cellular models of acute acetaminophen overdose

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Crucially, pharmacological inhibition of CFTR in the PDECs (using CFTRinh-172) led to a ~54% reduction in insulin secretion from the underlying islets, whereas direct application of inhibitor to islets alone had no effect, underscoring a ducto-insular cross-talk mediated by CFTR function

Most clinical research on levocarnitine for weight management used doses of 1,000 to 3,000 mg daily