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GLP-1 RAs provide sustained central and peripheral GLP-1R activation that blunts appetite via hypothalamusvagusNTS circuits, improves metabolic health, and may reduce alcohol and other substance-related craving and reward signals

2022;387(12):1089-1098 and Supplementary Appendix

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CAS 170851-70-4 uniquely identifies the Ipamorelin peptide for accurate research documentation and traceability

In rectosigmoid biopsies from patients with constipation-predominant IBS and healthy controls, GLP-1R was significantly downregulated in IBS individuals compared to controls [55]