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Poly ADP-ribosylation, also known as PARylation, is a type of PTM in which polymers of ADP-ribose are covalently attached to target proteins by PAR polymerase (PARP) enzymes, resulting in a dramatic electrostatic change of the acceptor protein surface 128

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Weight loss benefits became evident as a secondary finding during diabetes studies in the early 2000s, prompting separate research programs and regulatory pathways for metabolic health applications