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The basic principle of mendelian randomization is that genetic variants that either alter the level of, or mirror the biological effects of, plasma vitamin B12 that itself could affect the risk of cancer should be related to cancer risk to the extent predicted by their influence on plasma B12
Conflict of interest JT has given Scientific advice to AlfaWassermann, Allergan, Christian Hansen, Danone, Grnenthal, Ironwood, Janssen, Kiowa Kirin, Menarini, Mylan, Neutec, Novartis, Noventure, Nutricia, Shionogi, Shire, Takeda, Theravance, Tramedico, Truvion, Tsumura, Zealand, and Zeria pharmaceuticals and has served on the Speaker bureau for Abbott, Allergan, AstraZeneca, Janssen, Kyowa Kirin, Menarini, Mylan, Novartis, Shire, Takeda, Truvion, and Zeria
G., Bollen, P
This structural heterogeneity necessitates the application of extraction techniques specifically designed for the distinct properties of each compound and the nature of the sample matrix (32)
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