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In incretin-based trials, early weeks are often dominated by titration and tolerability: nausea, diarrhea, constipation, vomiting, appetite changes, and satiety shifts

Studies on humans reported a rapid GLP-1 release after the oral administration of glucose, which reaches its maximum after about 30 min and keeps this maximal level of around 300% of the basal GLP-1 level in a plateau phase for approximately an additional hour

Potential side effects Similar to semaglutide: nausea, diarrhea, or appetite changes

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