what is the mechanism of action of glp-1 agonists receptor (GLP-1RAs): cardiovascular actions and therapeutic potential GLP-1 Receptor Agonists as Treatments

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Quick Answer: GLP-1 medications typically cause modest blood pressure reductions of 2-6 mmHg, but some patients may experience symptomatic low blood pressure, particularly when combined with antihypertensive medications, significant weight loss, or dehydration from gastrointestinal side effects

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On legality: it was never FDA approved, partly because its lethal dose is unknown