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First-in-Human trials follow a cautious and progressive dose-escalation approach designed to support continuous safety evaluation throughout the study

Patients taking other medications, especially those that also affect the central nervous system, should provide their healthcare provider with a complete list of their current medications

Highly infiltrative growth patterns, cellular and molecular heterogeneity, a subpopulation of cells highly resistant to radiotherapy and chemotherapy, called glioma stem-like or glioma-initiating cells 3,4,5,6 , and a complex network of interactions between different tumor cell populations and the tumor microenvironment 7 have been held responsible for escape from current therapies

Effects of topically applied liquid N-acetylcysteine for the management of burning mouth syndrome

Drug Discovery Today , 20 (1), 122128