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2 , 699706.e691 (2020)
A medical evaluation is recommended before starting peptide therapy
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Given that cytosolic CRAT-generated acetyl-CoA can produce malonyl-CoA, an inhibitor of fatty acid oxidation [1, 33], we speculate that, in addition to the suppression of mitochondrial biogenesis by increasing acetyl-CoA-mediated acetylation of PGC-1, the anti-tumoral activity of CRAT may also be partially achieved by inhibiting fatty acid oxidation, which still needs further investigation
Specific drugs may carry a boxed warning, but most of the time it applies to a whole drug class
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