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Hum Reprod (2012) 27(4):108895

Moreover, the majority of supporting studies are based on small, single-center cohorts and lack external validation, thereby restricting their generalizability

SGLT2 inhibitors during pregnancy Animal None of the SGLT2 inhibitors showed developmental toxicity when a dose not resulting in maternal toxicity was administered during the interval coinciding with the first trimester period of organogenesis except for canagliflozin, where ossification delays of the metatarsal bones were seen ( Table 2 )

Recomendaciones de seguridad : iniciar con la dosis ms baja y titular gradualmente, asegurar hidratacin adecuada, mantener suplementacin vitamnica rigurosa, y establecer seguimiento multidisciplinario

La L-carnitina es perfecta para combinar con otros suplementos