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Shiseido's unique and ultra-advanced 18 micro-point applicator with PreciseDelivery Technology enables skin to receive effective ingredients more precisely through mechanical stimulation for intensified benefits

Hence the differences between both structures in terms of antigenic epitopes are minimal, making it more challenging to specifically target the prefusion structure

Members of Group 3 had only a sham surgery and served as the non-treated controls

Significant wrinkle reduction typically appears between weeks eight and twelve of consistent use

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