Knockout of the Mouse Glutamate Cysteine Ligase Catalytic Subunit (Gclc) Gene: Embryonic Lethal When Homozygous, and Proposed Model for Moderate Glutathione Deficiency When Heterozygous
The use of a BPC peptide salt according to any of the claims 1 to 9 for the preparation of a compatible, storage-stable pharmaceutical composition according to claim 10 for the treatment of:disturbances connected with either nitric oxide (NO) formation or impaired NO-system functions, in particular, hypertension, angina, impotence, circulatory and septic shock, stroke, inflammation, respiratory distress syndrome, adhesion and aggregation of platelets and leukocytes, endothelial dysfunction, gastrointestinal lesions, peristalsis disturbances, diabetes pancreatitis, hypotension and Parkinson's disease;dysfunctions or hyperfunctions of somatosensory nerves, in particular, sensory neuropathy, postherpetic neuralgia, atopic dermatitis, impaired healing of injured tissue, acquired cold and heat urticaria, psoriasis, bullous pemphigoid, eczema, photodermatoses, chronic arthritis, gastrointestinal lesions and specific or non-specific hyperreactivity of upper and lower respiratory tracts (asthma, rhinitis);endothelium disturbances;wounds, ulcers;conditions relating to acute and/or chronic inflammation, in particular, chronic arthritis, and disorders related with delayed type of hypersensitivity, and gastrointestinal lesions;liver disorders, organ lesions induced by free radicals specifically caused by irradiation;disorders connected with cathecholaminergic system disturbances, in particular, schizophrenia, amphetamine challenge effects, drug abuse;stress related conditions;acute pancreatitis
Abstract The glutathione (GSH) system is considered to be one of the most powerful endogenous antioxidant systems in the cardiovascular system due to its key contribution to detoxifying xenobiotics and scavenging overreactive oxygen species (ROS)
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Antimicrobial peptides targest microbial surface structure, while the GM simultaneously induces local immunoglobulin synthesis to limit pathogen translocation
