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Adipocyte accumulation in the bone marrow during obesity and aging impairs stem cell-based hematopoietic and bone regeneration

The NHS recognises that ensuring sufficient B12 levels before conception and throughout pregnancy supports maternal health, reduces the risk of megaloblastic anaemia, and provides the foundation for healthy fetal development

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Compared to obese wild-type control animals, obese IFN- knockouts exhibit better IS, smaller adipocyte size, and lower cytokine expression [79]