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Expectedly, the current data showed that sildenafil antagonized the antinociceptive effect of nicorandil in both CCI model and formalin test

Indeed, the development of single-cell RNA sequencing analyses has led to the detection of microglial heterogeneity in both physiological and pathological conditions, suggesting that microglial activation is a dynamic response involving transcriptionally and spatially different subpopulations (Keren-Shaul et al., 2017

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An unpaired cysteine, which is exceptional in the SRCR-SF, is present in both SRCR2 (C191) and SRCR3 (C300) between C4 and C5 (Fig