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Hippuric acid, a glycine conjugate involved in liver detoxification, showed a decrease post-seizure, likely indicating a depletion of glycine, which also functions as a neurotransmitter in inhibitory signalling in the central nervous system 33

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doi: 10.1073/pnas.0902204106 93 RohJLKimEHJangHJParkJYShinD

By contrast, peptides are shorter chains that are typically two-dimensional

Together these data confirm the expectation that active 6-AH analogs can block dimerization and further that dimerization inhibitory potential of an analog translates, at least qualitatively, to its capacity to block HGF-dependent processes