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La vida media biolgica del GLP-1 in vivo es corta (aproximadamente 2 minutos) y se degrada rpidamente por la accin de la enzima dipeptidil dipeptidasa-4 (DPP-4) 21 , por tanto, el enfoque farmacolgico ha sido dirigido a prolongar la vida media del GLP-1, ya sea por modificacin estructural del pptido original o por inhibicin de la enzima DDP-4

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Kirby doesnt believe frequency bias is at work here, though

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Furthermore, in colorectal cancer, ROS generated from inflammatory cells, such as neutrophils and macrophages, play a critical role in the progression of colorectal cancer by inducing DNA damage, promoting epithelial cell proliferation, and impairing apoptosis