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These potential benefits make it a compound of interest beyond pure metabolic applications

You take certain medications: Long-term use of proton pump inhibitors (for acid reflux) or metformin (for diabetes) can interfere with B12 absorption

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Aging and kidney biology Likewise, Related ERR-agonist work has examined mitochondrial dysfunction, inflammation, fibrosis, and renal function in aging models

The pharmacology is well described in the peer-reviewed literature, but clinical effect sizes vary by indication, dosing, individual factors, and adherence, which is a large part of why frequency cannot be generalized