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2019 ESC guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD: the task force for diabetes, pre-diabetes, and cardiovascular diseases of the European Society of Cardiology (ESC) and the European Association for the Study of Diabetes (EASD)

observed that in the TRE group, the decline in the bone formation marker P1NP was significantly attenuated (-0.22 vs -4.07 ng/mL), indicating potential bone-protective effects

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This mechanism of action makes GHRP-6 a selective GH secretagogue, as it only stimulates growth hormone release and does not affect the secretion of other hormones