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Further in vitro ubiquitination assays revealed that IpaH1.4 mainly catalyzes the K48-linked ubiquitination of RNF213 in vitro (Supplementary Fig

The clinical literature shows that myo-inositol, particularly at doses of 24 g/day, consistently demonstrates statistically significant effects on insulin sensitivity, androgen levels, menstrual cyclicity, and ovulation rates in women with PCOS, as well as measurable improvements in oocyte quality markers in certain infertility populations

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