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(The concept of BMI itself is not without controversy

Tablets still have their place though

The resulting cartilage fragments, upon phagocytosis by type A synovial fibroblasts, induce the secretion of various proinflammatory cytokines, thus forming a vicious cycle of inflammation and cartilage degradation that perpetuates RA pathogenesis ( The regulatory effect of the immune microenvironment in the pathogenesis of RA is attracting considerable research interest

While these synthetic GLP-1 agonists have demonstrated remarkable efficacy in clinical trials, they are associated with a range of side effects, including common gastrointestinal issues such as nausea, vomiting, diarrhea, and constipation, which are often dose-dependent (Kommu S et al., 2025